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yac 1 cell  (ATCC)


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    ATCC yac 1 cell
    Yac 1 Cell, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 748 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/yac+1+cells/YAC-1/us12636307-237-375-387
    Average 96 stars, based on 748 article reviews
    yac 1 cell - by Bioz Stars, 2026-09
    96/100 stars

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    Cell Culture:

    Article Title: A Microbiota- and IL-15-Dependent Innate-Like B Cell Progenitor Expressing E4BP4.
    Article Snippet: Mouse TLR9 agonist (ODN 1585, #tlrl-1585) and ODN control were purchased from Invivogen. .. Cells: The YAC-1 cells (thymoma, ATCC# TIB-160), and RMA cells (obtained from Nanjing Cobioer Biosciences) were cultured in RPMI 1640 medium (STEMCELL) supplemented with 10% fetal bovine serum (STEMCELL). ..

    Article Title: A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4
    Article Snippet: Mouse TLR9 agonist (ODN 1585, #tlrl‐1585) and ODN control were purchased from Invivogen. .. The YAC‐1 cells (thymoma, ATCC# TIB‐160), and RMA cells (obtained from Nanjing Cobioer Biosciences) were cultured in RPMI 1640 medium (STEMCELL) supplemented with 10% fetal bovine serum (STEMCELL). ..

    Article Title: Suppressor effects of carrots on azoxymethane/dextran sulfate sodium-induced colon cancer according to cultivation method
    Article Snippet: .. The YAC-1 cells utilized in this study were obtained from the American Type Culture Collection (Manassas, Virginia, USA) and cultured in RPMI 1,640 medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin (PS), and subcultured 3–4 times per week for future experiments. ..

    Cytotoxicity Assay:

    Article Title: Niacin Mitigates Cyclophosphamide-Induced Immunosuppression by Maintaining Intestinal Homeostasis and Regulating the HCAR2/NLRP3 and PTGS2/PGE2 Signaling Pathways
    Article Snippet: .. In the NK cell cytotoxicity assay, YAC-1 cells (ATCC, Manassas, VA, USA) served as target cells, while the effector cells were splenocytes from control or niacin-treated groups. ..

    Article Title: Niacin Mitigates Cyclophosphamide-Induced Immunosuppression by Maintaining Intestinal Homeostasis and Regulating the HCAR2/NLRP3 and PTGS2/PGE2 Signaling Pathways.
    Article Snippet: .. In the NK cell cytotoxicity assay, YAC-1 cells (ATCC, Manassas, VA, USA) served as target cells, while the effector cells were splenocytes from control or niacin-treated groups. ..

    Control:

    Article Title: Niacin Mitigates Cyclophosphamide-Induced Immunosuppression by Maintaining Intestinal Homeostasis and Regulating the HCAR2/NLRP3 and PTGS2/PGE2 Signaling Pathways
    Article Snippet: .. In the NK cell cytotoxicity assay, YAC-1 cells (ATCC, Manassas, VA, USA) served as target cells, while the effector cells were splenocytes from control or niacin-treated groups. ..

    Article Title: Niacin Mitigates Cyclophosphamide-Induced Immunosuppression by Maintaining Intestinal Homeostasis and Regulating the HCAR2/NLRP3 and PTGS2/PGE2 Signaling Pathways.
    Article Snippet: .. In the NK cell cytotoxicity assay, YAC-1 cells (ATCC, Manassas, VA, USA) served as target cells, while the effector cells were splenocytes from control or niacin-treated groups. ..

    Isolation:

    Article Title: Spirulina maxima extract enhances immune function via NF-κB and MAPK pathways and ameliorates cyclophosphamide-induced immunosuppression and intestinal damage in mice
    Article Snippet: .. Splenocytes were isolated from fresh mouse spleen and YAC-1 cells were obtained from ATCC. ..

    Activity Assay:

    Article Title: Effects of Limosilactobacillus fermentum KBL375 on Immune Enhancement and Gut Microbiota Composition in Cyclophosphamide-Induced Immunosuppressed Mice.
    Article Snippet: Cells were filtered using a 30-μm cell strainer (SPL Life Science) and counted for further use. .. To evaluate the NK cell cytotoxic activity of KBL375 in vitro, splenocytes were used as effector cells, and YAC-1 cells (ATCC, Rockville, MD, USA) acted as target cells. ..

    In Vitro:

    Article Title: Effects of Limosilactobacillus fermentum KBL375 on Immune Enhancement and Gut Microbiota Composition in Cyclophosphamide-Induced Immunosuppressed Mice.
    Article Snippet: Cells were filtered using a 30-μm cell strainer (SPL Life Science) and counted for further use. .. To evaluate the NK cell cytotoxic activity of KBL375 in vitro, splenocytes were used as effector cells, and YAC-1 cells (ATCC, Rockville, MD, USA) acted as target cells. ..



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    Functional characterization of murine CD127 + NK cells. ( a ) Cytotoxic activity of sorted, freshly isolated CD127 + and CD127 − NK cells from the spleen and lymph nodes of adult C57BL/6 mice ( n = 5) was assessed against YAC-1 target cells using a 51 Cr-release assay at the indicated effector-to-target (E/T) ratios. CD127 + NK cells exhibited measurable cytotoxic activity; however, their lytic capacity was significantly lower than that of CD127 − NK cells at multiple E/T ratios. ( b ) Intracellular IFN-γ production by CD127 + and CD127 − NK cells following stimulation with anti-NK1.1 mAb (PK136). Representative flow cytometric plots are shown, with numbers in the quadrants indicating the percentage of cells in each region. Data are presented as mean ± SD. Statistical comparisons between CD127 + and CD127 − subsets were performed using an unpaired two-tailed Student’s t -test. * p < 0.05, ** p < 0.01. IFN-γ—interferon-γ; mAb—monoclonal antibody.

    Journal: International Journal of Molecular Sciences

    Article Title: CD127 + Natural Killer Cells Represent a Distinct, Interleukin-15-Independent and Thymus-Independent Subset in Mice

    doi: 10.3390/ijms27062667

    Figure Lengend Snippet: Functional characterization of murine CD127 + NK cells. ( a ) Cytotoxic activity of sorted, freshly isolated CD127 + and CD127 − NK cells from the spleen and lymph nodes of adult C57BL/6 mice ( n = 5) was assessed against YAC-1 target cells using a 51 Cr-release assay at the indicated effector-to-target (E/T) ratios. CD127 + NK cells exhibited measurable cytotoxic activity; however, their lytic capacity was significantly lower than that of CD127 − NK cells at multiple E/T ratios. ( b ) Intracellular IFN-γ production by CD127 + and CD127 − NK cells following stimulation with anti-NK1.1 mAb (PK136). Representative flow cytometric plots are shown, with numbers in the quadrants indicating the percentage of cells in each region. Data are presented as mean ± SD. Statistical comparisons between CD127 + and CD127 − subsets were performed using an unpaired two-tailed Student’s t -test. * p < 0.05, ** p < 0.01. IFN-γ—interferon-γ; mAb—monoclonal antibody.

    Article Snippet: Briefly, NK cell-mediated cytotoxicity was assessed by measuring 51 Cr-release following the incubation of freshly isolated, unstimulated effector cells with 51 Cr-labeled YAC-1 target cells (ATCC).

    Techniques: Functional Assay, Activity Assay, Isolation, Release Assay, Two Tailed Test